Protocol for management of child with COVID-19
Protocol for management of pregnant women with suspected symptoms of COVID-19
Protocol for management of adult with COVID-19
Key Updates to the Guidelines
Updated to incorporate recommendations for when to use combination anti-SARS-CoV-2 monoclonal antibodies and tocilizumab (in combination with dexamethasone) in certain patients with COVID-19.
A new subsection has been added to discuss the emerging information on SARS-CoV-2 variants of concern.
A new subsection describes reports of SARS-CoV-2 reinfection in individuals who had previously documented COVID-19. The discussion on patients who experience persistent symptoms or organ dysfunction after acute COVID-19 has also been updated.
This section now incorporates information and recommendations from the Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal Antibodies for the Treatment of COVID-19 that was released on April 8, 2021. This section also includes information on the various reported SARS-CoV-2 variants and the potential impact of mutations on in vitro susceptibility to different anti-SARS-CoV-2 monoclonal antibodies.
High-titer convalescent plasma is available through a Food and Drug Administration Emergency Use Authorization for the treatment of certain hospitalized patients with COVID-19. This section has been updated to include new recommendations regarding the use of convalescent plasma in hospitalized patients with COVID-19 (including those who have impaired humoral immunity) and in nonhospitalized patients with COVID-19.
Interleukin-6 Inhibitors (With Focus on Tocilizumab)
Updated to incorporate and expand on the Panel’s statements on the use of tocilizumab for the treatment of COVID-19 that were released on February 3 and March 5, 2021. This section includes considerations for using tocilizumab in combination with dexamethasone in certain hospitalized patients who are exhibiting rapid respiratory decompensation due to COVID-19.
This section now includes expanded discussions on treatment considerations for children with acute COVID-19. Additions to the section include updated information on the epidemiology and risk factors for COVID-19 in children, vertical transmission of SARS-CoV-2 infection, and multisystem inflammatory syndrome in children (MIS-C).
Other Updates to the Guidelines
The following sections have been updated to include recommendations and special considerations for SARS-CoV-2 vaccination in specific populations:
- Special Considerations in Adults and Children With Cancer
- Special Considerations in Persons with HIV
- Special Considerations in Solid Organ Transplant, Hematopoietic Stem Cell Transplant, and Cellular Therapy Candidates, Donors, and Recipients
The information in the following sections has also been updated: